At Best of Best Review, we are thrilled to announce MailGuard 365 as the Best AI-Enhanced Email Security Solution in the U.S. of 2025. Recognized for its innovative approach to preventing AI-driven email threats before they reach end users, MailGuard 365 stands as a trailblazer in the cybersecurity space, offering unmatched protection for businesses against the most sophisticated digital attacks.

Why MailGuard 365 is the Best

As email remains the most common attack vector in modern cybersecurity breaches, MailGuard 365 has taken a revolutionary approach by focusing on AI-enhanced email threats—the very type of attack that often evades traditional security measures. The platform effectively blocks threats before user engagement, meaning employees never see potentially dangerous emails in their inbox. This proactive strategy gives businesses peace of mind, knowing their sensitive data and systems are safeguarded from even the most deceptive email scams.

What truly sets MailGuard 365 apart is its seamless integration with Microsoft 365, the most widely used cloud productivity platform in the world. By building MailGuard 365 directly within the Microsoft ecosystem, businesses can deploy robust protection without disrupting employee workflows or requiring time-consuming retraining. This integration ensures zero impact on daily work, making it easier for organizations to protect themselves against impersonation and payment fraud, some of the most common and financially damaging email-based threats.

Proven Effectiveness with Real-Time Results

MailGuard 365 doesn’t just claim to be effective—it proves it. Every time the service intercepts a threat, it provides verifiable Microsoft 365 evidence and timestamps, offering leadership teams clear, actionable insights into the security of their email environment. This transparency sets MailGuard 365 apart from other solutions that rely on vague reports or dashboards. Executives can rest assured knowing that the protection is measurable, auditable, and reliable.

This capability is especially critical as organizations face growing pressure to provide proof of compliance with security standards. By offering evidence-based reports and compliance-ready data, MailGuard 365 makes it easier for businesses to meet stringent cybersecurity regulations.

Trusted Leadership

Craig McDonald, founder and CEO of MailGuard, has led the company with a vision grounded in real-world experience. After his previous business was brought to a halt by a single email attack, Craig set out to build a solution that could stop threats before they reach the user. His foresight led to the development of MailGuard 365, which quickly gained recognition from industry leaders, including Satya Nadella, CEO of Microsoft, who described the innovation as “the type of innovation that we want to see.”

Craig's leadership and the team’s commitment to building a solution that complements, rather than replaces, Microsoft’s native security tools have earned MailGuard 365 a reputation for excellence in email security.

Why MailGuard 365 Stands Above the Competition

MailGuard 365 offers several key advantages that put it ahead of competitors in the email security space:

• AI-enhanced protection: MailGuard 365’s focus on AI-driven threats, including clean-looking attacks like impersonation and payment fraud, prevents them from reaching end users.

• Seamless Microsoft 365 integration: Unlike other solutions, MailGuard 365 is built within Microsoft 365, ensuring businesses can implement email security without disrupting employee productivity.

• Zero retraining: The platform requires no additional training for staff, allowing employees to continue using Microsoft 365 without learning new systems or behaviors.

• Proof of effectiveness: MailGuard 365 offers evidence and timestamps for every intercepted threat, ensuring that businesses can verify the protection and efficacy of their solution.

• ISO/IEC 27001:2022 certification: MailGuard 365 has earned one of the highest certifications for information security, further establishing its trustworthiness and commitment to cybersecurity best practices.

• Global trust: Serving clients in 141 countries and 17 currencies, MailGuard 365 has established itself as the go-to email security solution for organizations across the globe.

Real-World Impact

The impact of MailGuard 365 is tangible, with businesses reporting higher levels of confidence in their email security infrastructure. By preventing threats before they can even reach the user, MailGuard 365 significantly reduces the risk of cyberattacks like Business Email Compromise (BEC), which continues to be one of the most financially damaging cybercrimes in the world. This type of protection is a must for businesses of all sizes, particularly those in high-risk industries such as finance, healthcare, and government.

MailGuard 365 in Action: What Clients Are Saying

MailGuard 365 has earned widespread praise from its customers, who appreciate its simplicity, effectiveness, and lack of disruption. In their own words:

• “MailGuard 365 has saved us time and effort by stopping threats before they even land in our inboxes. The fact that we don't need to retrain staff or adjust workflows has been a game-changer for us.” — IT Manager, Fortune 500 Company

• “As a financial services firm, email security is critical. With MailGuard 365, we have peace of mind knowing that we’re proactively blocking threats, and we can see the results right in Microsoft 365.” — CISO, Major Bank

The MailGuard 365 Advantage

• Zero impact on workflows: Employees won’t need to change how they work.

• AI-driven threat prevention: Stops realistic-looking scams before users even see them.

• Seamless Microsoft 365 integration: Protection built right into the platform your staff already uses.

• Proof of protection: Evidence and timestamps for every blocked threat.

• ISO/IEC 27001:2022 certification: Highest level of cybersecurity standards.

• Global reach: Available in 141 countries, protecting businesses worldwide.

For more information on how MailGuard 365 can safeguard your organization from the most advanced email threats, visit their website.